Study on the Mechanism of Coptis Chinensis in the Treatment of Diabetic Nephropathy Based on Network Pharmacology

To investigate the therapeutic effects of Coptis chinensis on diabetic nephropathy using systematic pharmacological techniques. The TCMSP database was used to search main components and related targets chinensis; GeneCards CTD databases were screen disease nephropathy, intersection taken plotted in Venn diagram; target protein interaction (PPI) network constructed from STRING database; DAVID 6.8 online tool GO KEGG enrichment analyses performed obtain key signaling pathways acting nephropathy. Fourteen effective 186 obtained database, 3358 summary two databases, CTD. 118 intersecting diseases obtained, core TP53, MAPK1, AKT1, RELA, TNF, CAV1, RXRA, which may act MAPK pathway PI3K-Akt regulate inflammatory response oxidative stress generated by process, thus reducing symptoms. can exert its mechanism action for treatment through multiple with pathways.